2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-77644
    5'-Deoxy-5'-iodouridine
    5'-Deoxy-5'-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-Deoxy-5'-iodouridine
  • HY-137658
    Purine riboside triphosphate
    Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.
    Purine riboside triphosphate
  • HY-138614
    5'-O-DMT-2'-O-TBDMS-Ac-rC
    		99.80%
    5'-O-DMT-2'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-2'-O-TBDMS-Ac-rC
  • HY-160042
    AFP aptamer sodium
    AFP aptamer sodium is an aptamer that specifically targets the liver cancer biomarker alpha-fetoprotein (AFP). AFP aptamer sodium can be used as a recognition molecule for AFP, with a linear detection range of 12.5-800 ng/mL.
    AFP aptamer sodium
  • HY-107372S
    Uridine triphosphate-13C9,15N2 sodium
    Uridine triphosphate-13C9,15N2 (UTP-13C9,15N2) sodium is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
    Uridine triphosphate-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>2</sub> sodium
  • HY-160129
    Centanamycin
    Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening.
    Centanamycin
  • HY-104017
    DMT-2'-O-MOE-rA(Bz) phosphoramidite
    		98.0%
    DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenine nucleoside analog. DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used in research on oligonucleotide synthesis.
    DMT-2'-O-MOE-rA(Bz) phosphoramidite
  • HY-W009016
    2’,3’,5’-Tri-O-acetyl adenosine
    		99.55%
    2’,3’,5’-Tri-O-acetyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’,3’,5’-Tri-O-acetyl adenosine
  • HY-W357202
    7’-OH-N-trityl morpholinothymine
    7’-OH-N-trityl morpholinothymine (PMO Thymidine Precusor) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7’-OH-N-trityl morpholinothymine
  • HY-138598
    5'-O-TBDMS-dG
    		98.83%
    5'-O-TBDMS-dG is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-TBDMS-dG
  • HY-128710
    2'-Fluorothymidine
    		99.07%
    2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research.
    2'-Fluorothymidine
  • HY-138607
    5'-O-DMT-N2-DMF-dG
    		99.09%
    5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-DMT-N2-DMF-dG
  • HY-B0228S8
    Adenosine-d-2
    		99.72%
    Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys
    Adenosine-d-2
  • HY-W353804
    2′-Deoxy-β-L-uridine
    		99.96%
    2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase.
    2′-Deoxy-β-L-uridine
  • HY-152622
    3’-Deoxy-5-methyluridine
    		99.09%
    3’-Deoxy-5-methyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-5-methyluridine
  • HY-154366
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
    		98.0%
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
  • HY-138880
    2′,3′-Di-O-acetylguanosine
    		98.00%
    2′,3′-Di-O-acetylguanosine is a nucleoside analog.
    2′,3′-Di-O-acetylguanosine
  • HY-13040
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
    		99.85%
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
  • HY-154524
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
    		99.68%
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
  • HY-W602640
    2'-Deoxyisoguanosine
    		99.81%
    2'-Deoxyisoguanosine is a purine nucleoside analog. 2'-deoxyisoguanosine has low potency and specificity in inhibiting tumor cell growth, similar to other telomerase inhibitors.
    2'-Deoxyisoguanosine